MCQ's on Drug Allergy for Medical and Staff Nurse Exams- [Objective]

1. Allergy is immediate hypersensitivity mediated by _____and mast cell degranulation
(A) IgG
(B) IgE
(C) IgM
(D) IgA
(E) IgD


2. Immediate Allergy is what type of hypersensitivity reaction
(A) Type I Hypersensitivity
(B) Type II Hypersensitivity
(C) Type III Hypersensitivity
(D) Type IV Hypersensitivity
(E) Type V Hypersensitivity


3. Hypersensitivity refers to undesirable reactions produced by
(A) circulatory system
(B) Respiratory system
(C) Immune System
(D) Endocrine system
(E) Autonomic nervous system


4. A mast cell (or mastocyt(E) is a resident cells of several types of tissues and contains many granules rich in_______.
(A) Acetylcholine
(B) Nicotine
(C) Epinephrine
(D) Histamine
(E) Histadine


5. The organ which involve most frequent hypersensitivity reaction is
(A) Liver
(B) Kidney
(C) Skin
(D) Lungs
(E) Stomach

6. Penicillin Allergy is usually caused by its chemical degradation to
(A) Penicillamine
(B) Penilloic acid
(C) Penicillenic acid
(D) Penaldic acid
(E) Penicilloic acid


7. Influenza vaccines can be contraindicated to patients who are allergic to the preservatives of the vaccine, e.g. _____
(A) Neomycin
(B) Streptomycin
(C) Gentamycin
(D) Doxycycline
(E) Clavulanic acid


8. Reduction in fever within ___ h withdrawal of drug strongly suggests that suspected drug causing allergy.
(A) 38 h
(B) 24h
(C) 48h
(D) 16 h
(E) 20 h


9. If fever is accompanied by ________, drug toxicity is more likely than allergy and is much more serious.
(A) Granulocytopenia
(B) Thrombocytopenia
(C) Histamine
(D) Leukopenia
(E) Hypotension


10. A mother comes to the pharmacy with her 3 ­years old son who has a cough. Which of the following list of symptoms is most likely to indicate an allergy?
(A) fever
(B) chesty cough
(C) rhinorrhoea
(D) headache
(E) malaise

11. The primary reason for a physician to prescribe human insulin is that:
(A) It has a faster onset of action than other insulin's
(B) It has a shorter duration of action than other insulin's
(C) It can be given to patients who have an allergy to animal insulin's
(D) It is more effective in preventing the complications of diabetes than animal insulin's
(E) It is more sterile than other insolines.


12. Immediate allergy reaction (type I allergic reaction) is:
(A) An allergic or immune response that begins within a period lasting from a few minutes to about an hour after exposure
to an antigen to which the individual has been sensitized
(B) An allergic reaction that becomes apparent only hours after contact
(C) An allergic reaction that results from the formation of antigen ­antibody complexes between a foreign antigen and IgM or IgG immunoglobulins.
(D) An allergic reaction that is due to the presence of elevated levels of antigen­ antibody complexes that cause tissue damage
(E) It occurs during blood transfusion reactions and in hemolytic disease of the newborn.


13. Immunodeficiency:
(A) A localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes a loss of function
(B) A disorder or deficiency of the normal immune response
(C) A disease resulting from an immune reaction produced by an individual's white blood cells or antibodies acting on the body's own tissues or extracellular proteins
(D) A disease caused by immune system when the drug passes 1st pass effect and damage the liver.
(E) It is an immunity disorder which is genetically transferred.


14. Delayed allergy reaction (type IV allergic reaction) is:
(A) An An allergic or immune response that begins within a period lasting from a few minutes to about an hour after exposure to an antigen to which the individual has been sensitized
(B) An allergic reaction that becomes apparent only hours after contact
(C) An allergic reaction that results from the formation of antigen­antibody complexes between a foreign antigen and IgM
(D) allergic reaction that is due to the presence of elevated levels of antigen­antibody complexes that cause tissue damage
(E) An allergic disorder which is transferred genetically.


15. Which one of the following is a false statement about atopic eczema?
(A) It commonly begins by drug reaction.
(B) Super­added herpes simplex infection is a serious complication.
(C) The serum IgE level is normally raised.
(D) The skin lesions are typically itchy.
(E) Treatment with systemic steroids is often necessary.


16. Which one of the following statements is false ? Allergic asthma is characterized by:
(A) Response to cyclosporin therapy in severe disease.
(B) Is characterized by reversible airways obstruction.
(C) T2 cells are found in bronchoalveolar lavage fluid.
(D) Affects 5% of the population.
(E) Is diagnosed routinely by use of ELISA

Go to next Page:

Part 1Part 2Part 3