Most Asked 100 MCQ from Analgesics and Antipyretics for Staff Nurse

<div dir="ltr" style="text-align: left;" trbidi="on"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgkRJ89UXSiZ8tTPVcE-M3lqqn8K0lF_MxGVzyQSDpzjo-wg23n5N57cn0pVhU-DY3s8y3jQmcyBieBrgm9kTKUiaeELyCHb28z7EURxpyMcvz2Y8wltOoh2b6vgWIBg9NWj1hTw1X6WmJU/s1600/analgesics+1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img alt="Most Asked 100 MCQ from Analgesics and Antipyretics for Staff Nurse" border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgkRJ89UXSiZ8tTPVcE-M3lqqn8K0lF_MxGVzyQSDpzjo-wg23n5N57cn0pVhU-DY3s8y3jQmcyBieBrgm9kTKUiaeELyCHb28z7EURxpyMcvz2Y8wltOoh2b6vgWIBg9NWj1hTw1X6WmJU/s1600/analgesics+1.jpg" title="Most Asked 100 MCQ from Analgesics and Antipyretics for Staff Nurse" /></a></div><div dir="ltr" style="text-align: left;" trbidi="on"><div class="content_1">1. â­-Aminoethylimidazole is?<br />(a) 2­methyl histamine<br />(b) Histamine<br />(c) 2­pyridyl ethylamine<br />(d) 4­methyl histamine<br /><input color="black" onclick="value=("Answer : (b) Histamine ")" type="button" value="Show Answer" /><br /><br />2. Agents that often cause vasoconstriction include all of the following except<br />(a) Angiotensin II<br />(b) Methysergide<br />(c) PGF2a<br />(d) Prostacyclin<br />(e) Thromboxane<br /><input color="black" onclick="value=("Answer : (d) Prostacyclin ")" type="button" value="Show Answer" /><br /><br />3. Inflammation is a complex tissue reaction that includes the release of cytokines, leukotrienes, prostaglandins, and peptides. Prostaglandins involved in inflammatory processes are produced from arachidonic acid by<br />(a) Cyclooxygenase 1<br />(b) Cyclooxygenase 2<br />(c) Glutathione – S – transferase<br />(d) Lipoxygenase<br />(e) Phospholipase A2<br /><input color="black" onclick="value=("Answer : (b) Cyclooxygenase 2 ")" type="button" value="Show Answer" /><br /><br />4. A 60­year­old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure?<br />(a) Leukotriene LTD4 or its analogs<br />(b) Prostaglandin E2 or its analogs<br />(c) Prostaglandin F2a or its analogs<br />(d) Slow­reacting substance of anaplylaxis (SRS­A)<br />(e) Thromboxane A2 or its analogs<br /><input color="black" onclick="value=("Answer : (c) Prostaglandin F2a or its analogs ")" type="button" value="Show Answer" /><br /><br />5. Which of the following is a reversible inhibitor of platelet cyclooxygenase?<br />(a) Alprostadil<br />(b) Aspirin<br />(c) Ibuprofen<br />(d) LTC4<br />(e) Misoprostol<br /><input color="black" onclick="value=("Answer : (c) Ibuprofen ")" type="button" value="Show Answer" /><br /><br />6. Vasodilation by prostaglandins involves<br />(a) Arterioles<br />(b) Precapillary sphincters<br />(c) Postcapillary venules<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : (d) All of the above ")" type="button" value="Show Answer" /><br /><br />7. Fentanyl transdermal patches have been used postoperatively to provide transdermal analgesia. The most dangerous adverse effect of this mode of administration is<br />(a) Cutaneous reactions<br />(b) Diarrhea<br />(c) Hypertension<br />(d) Relaxation of skeletal muscle<br />(e) Respiratory depression<br /><input color="black" onclick="value=("Answer : (e) Respiratory depression ")" type="button" value="Show Answer" /><br /><br /><a name="more"></a><br /><br />8. Opioid analgesics are either contraindicated or must be used with extreme caution in several clinical situations. For morphine, such situations do not include<br />(a) Aqueous diffusion<br />(b) Aqueous hydrolysis<br />(c) Lipid diffusion<br />(d) Pinocytosis or endocytosis<br />(e) Special carrier transport<br /><input color="black" onclick="value=("Answer : (e) Special carrier transport ")" type="button" value="Show Answer" /><br /><br />9. Following is an example of paraaminophenol NSAID<br />(a) Diclofenac<br />(b) Acetaminophen<br />(c) Piroxicam<br />(d) Celecoxib<br /><input color="black" onclick="value=("Answer : (b) Acetaminophen ")" type="button" value="Show Answer" /><br /><br />10. This drug, which does not activate opioid receptors, has been proposed as a maintenance drug in treatment programs for opioid addicts; a singly oral dose will block the effects of injected heroin for up to 48 hours<br />(a) Amphetamine<br />(b) Buprenorphine<br />(c) Naloxone<br />(d) Naltrexone<br />(e) Propoxyphene<br /><input color="black" onclick="value=("Answer : (d) Naltrexone ")" type="button" value="Show Answer" /><br /><br /><br />11. Which one of the following statements about dextromethorphan is accurate?<br />(a) Activates kappa receptors<br />(b) Analgesia equivalent to pentazocine<br />(c) Highly effective antiemetic<br />(d) Less constipation than codeine<br />(e) Use requires a prescription<br /><input color="black" onclick="value=("Answer : (d) Less constipation than codeine ")" type="button" value="Show Answer" /><br /><br />12. Which one of the following effects does not occur in salicylate intoxication ?<br />(a) Hyperventilation<br />(b) Hypothemia<br />(c) Metabolic acidosis<br />(d) Respiratory alkalosis<br />(e) Tinnitus<br /><input color="black" onclick="value=("Answer : (b) Hypothemia ")" type="button" value="Show Answer" /><br /><br />13. Which one of the following drugs is not useful in dysmenorrhea?<br />(a) Aspirin<br />(b) Colchicine<br />(c) Ibuprofen<br />(d) Rofecoxib<br />(e) Naproxen<br /><input color="black" onclick="value=("Answer : (b) Colchicine ")" type="button" value="Show Answer" /><br /><br />14. Following gold compound is generally administered orally<br />(a) Aurothioglucose<br />(b) Auronafin<br />(c) Gold sodium thiomalate<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : (b) Auronafin ")" type="button" value="Show Answer" /><br /><br />15. The main advantage of ketorolac over aspirin is that ketorolac<br />(a) Can be combined more safely with an opioid such as codeine<br />(b) Can be obtained as an over­the­counter agent<br />(c) Does not prolong the bleeding time<br />(d) Is available in a parenteral formulation that can be injected intramuscularly or intravenously<br />(e) Is less likely to cause acute renal failure in patients with some preexisting degree of renal impairment<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />16. A 45­year­old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti­inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side effects. Which one of the following drugs is most appropriate?<br />(a) Aspirin<br />(b) Celecoxib<br />(c) Ibuprofen<br />(d) Indomethacin<br />(e) Piroxicam<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />17. Following is an example of preformed and not lipid derived mast cell mediator of inflammatory process<br />(a) LTC4<br />(b) PGD2<br />(c) PAF<br />(d) Histamine<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />18. The toxicity spectrum of aspirin does not include<br />(a) Increased risk of encephalopathy in children with viral infections<br />(b) Increased risk of peptic ulcers<br />(c) Hyperprothrombinemia<br />(d) Metabolic acidosis<br />(e) Respiratory alkalosis<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />19. Accidental poisonings are common with both aspirin and ibuprofen, two OC drugs available in tasty chewable tablets. In cases of overdose, aspirin is more likely than ibuprofen to cause<br />(a) Autonomic Instability<br />(b) Hepatic necrosis<br />(c) Metabolic acidosis<br />(d) Thrombocytopenia<br />(e) Ventricular arrhythmias<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />20. A drug that decreases blood pressure and has analgesic and spasmolytic effects when given intrathecally is<br />(a) Atenolol<br />(b) Clonidine<br />(c) Morphine<br />(d) Nitroprusside<br />(e) Prazosin<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br /><br /></div><div class="content_2" style="display: none;">21. Cyclooxygenase­1 and –2 are responsible for<br />(a) The synthesis of prostaglandins from arachidonate<br />(b) The synthesis of leukotrienes from arachidonate<br />(c) The conversion of ATP to cAMP<br />(d) The metabolic degradation of cAMP<br />(e) The conversion of GTP to cGMP<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />22. Following agent is generally used in allergic rhinitis<br />(a) Beclomethasone<br />(b) Fluticasone<br />(c) Triamcinolone<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />23. The primary objective for designing drugs that selectively inhibit COX – 2 is to<br />(a) Decrease the risk of nephrotoxicity<br />(b) Improve anti­inflammatory effectiveness<br />(c) Lower the risk of gastrointestinal toxicity<br />(d) Reduce the cost of treatment of rheumatoid arthritis<br />(e) Selectively decrease thromboxane A2 without effects on other eicosanoids<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />24. A newborn was diagnosed as having a congenital abnormality that resulted in transposition of her great arteries. While preparing the infant for surgery, the medical team needed to keep the ductus arteriosus open. They did this by infusing<br />(a) Cortisol<br />(b) Indomethacin<br />(c) Ketorolac<br />(d) Misoprostol<br />(e) Tacrolimus<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />25. Acetyl salicylic acid is soluble in<br />(a) An aqueous base<br />(b) Water<br />(c) An aqueous acid<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />26. Decomposition of the acetyl salicylic acid at room temperature most likely would occur by<br />(a) Oxidation of the ester<br />(b) Reduction of the carboxylic acid<br />(c) Hydrolysis of the ester<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />27. Diamprit is an agonist of ______ receptors, except<br />(a) H1<br />(b) H2<br />(c) H3<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />28. Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions?<br />(a) Phospholipase<br /><br />(b) Lipoxygenase<br />(c) Cyclooxygenase­I<br />(d) Cyclooxygenase II<br />(e) Xanthine oxidase<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />29. Which of the following prostaglandin analogs is used specifically for the treatment of NSAID induced gastrointestinal ulcertation?<br />(a) Alprostadil<br />(b) Misoprostol<br />(c) Carboprost<br />(d) Dinoprostone<br />(e) Epoprostenol<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />30. Which of the following compounds is most likely to lower circulating levels of leukotrienes?<br />(a) Zileuton<br />(b) Montelukast<br />(c) Carprofen<br />(d) Aspirin<br />(e) Allopurinol<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />31. The action of aspirin that results in its greater efficacy as an antithrombotic (anti­platelet) drug is its ability to<br />(a) Inhibit lipoxygenase as well as cyclooxygenase<br />(b) Selectively inhibit cyclooxygenase I<br />(c) Inhibit leukocyte migration<br />(d) Promote uric acid excretion<br />(e) Acetylate cyclooxygenase<br /><input color="black" onclick="value=("Answer : E ")" type="button" value="Show Answer" /><br /><br />32. Which of the following drugs may be effective in the treatment of gouty arthritis by acting by two separate and distinct mechanisms?<br />(a) Allopurinol<br />(b) Probenecid<br />(c) Colchicine<br />(d) Indomethacin<br />(e) Sulfinpyrazone<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />33. Acute or chronic colchicine toxicity may be identified by which of the following signs/symptoms?<br />(a) Alopecia<br />(b) Blood dyscrasias<br />(c) Severe gastrointestinal upset<br />(d) All of the above<br />(e) None of the above<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />34. Patients taking chronic doses of non-selective non-steroidal anti­-inflammatory drugs (NSAIDs) should periodically be screened for which of the following toxicities?<br />(a) Nephrotoxicity<br />(b) Peripheral neuropathy<br />(c) Cardiotoxicity<br />(d) All of the above<br />(e) None of the above<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />35. Which of the following medications would represent arthritis therapy that is least likely to cause gastric ulceration?<br />(a) Aspirin<br />(b) Acetaminophen<br />(c) Piroxicam<br />(d) Meclofenamate<br />(e) Rofecoxib<br /><input color="black" onclick="value=("Answer : E ")" type="button" value="Show Answer" /><br /><br />36. In addition to their ability to decrease inflammatory prostaglandin synthesis, some non­steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to<br />(a) Inhibit leukocyte migration<br />(b) Inhibit leukotriene synthesis<br />(c) Stabilize lysosmal membranes<br />(d) All of the above<br />(e) None of the above<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br /><br />37. The termination of heparin activity by protamine sulfate is due to<br />(a) A chelating action<br />(b) The inhibition of gastrointestinal absorption of heparin<br />(c) The displacement of heparin­plasma protein binding<br />(d) An acid­base interaction<br />(e) The prothrombin­like activity of protamine<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />38. In gastrointestinal tract, serotonin causes<br />(a) Contraction of gastrointestinal muscles<br />(b) Decreased muscle tone<br />(c) Decreased peristalsis<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />39. A FDA – approved ingredient for protection against painful sensitivity of the teeth due to cold, heat, acids, sweets or contact is<br />(a) Dicalcium phosphate<br />(b) Sodium lauryl sulfate<br />(c) 5% potassium nitrate<br />(d) Zinc chloride<br />(e) Calcium carbonate<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />40. Which local anesthetic should be used to treat symptoms of pain, itching, burning, and disconfort in patients with an established lidocaine allergy?<br />(a) Tetracaine<br />(b) Dibucaine<br />(c) Pramoxine<br />(d) Benzocaine<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br /><br /></div><div class="content_3" style="display: none;">41. What is the most commom sign/symptom of hemorrhoids?<br />(a) Bleeding<br />(b) Pain<br />(c) Seepage<br />(d) Pruritus<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />42. Which of the following agents is designated as a safe and effective analgesic, anesthetic and antipruritic by the Food and Drug Administration?<br />(a) Witch hazel<br />(b) Juniper tar<br />(c) Hydrocortisone<br />(d) Phenylephrine<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />43. A 65­year­old is interested in taking ginkgo. Which of the following statements is correct regarding ginkgo?<br />(a) Ginkgo is contraindicated in diabetes and pregnancy<br />(b) There is a drug­herb interaction between ginkgo and aspirin<br />(c) Toxic effects include hypertension and cardiac arrest<br />(d) There is a drug­herb interaction between ginkgo and phenelzine<br />(e) Ginkgo is contraindicated in patients with gallstone pain<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />44. All of the following medications should not be used routinely in pregnant patients during the third trimester except<br />(a) Acetaminophen<br />(b) Nonsteroidal anti­inflammatory drugs<br />(c) Warfarin<br />(d) Lithium<br />(e) Aspirin<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />45. Which of the following statements best describes the usual course of rheumatoid arthritis?<br />(a) It is an acute exacerbation of joint pain treated with short­term anti­inflammatory therapy<br />(b) It is a chronic disease characterized by acute changes within nonsynovial joints<br />(c) It is an acute disease that is characterized by rapid synovial changes due to inflammation<br />(d) It is a chronic disease characterized by acuteexacerbations followed by remissions with consequences associated with chronic inflammatory changes<br />(e) It is a joint disease characterized by a marked loss of calcium from the bones and a resultant thinning of the bones<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />48. In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is<br />(a) Acid – base and electrolytc disturbances<br />(b) Hypersensitivity and idiosyncratic reactions<br />(c) Gastric mucosal damage<br />(d) Salicylism<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />47. Generally the earliest manifestation of salicylism is<br />(a) Visual disturbance<br />(b) Excitement<br />(c) Hyperventillation<br />(d) Tinnitus<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />48. All of the following statements concerning an acute gouty arthritis attack are correct except<br />(a) The diagonosis of gout is assured by a good therapeutic response to colchicines because no other form of arthritis responds to this drug<br />(b) To be assured of the diagnosis, monosodium urate crystals must be identified in the synovial fluid of the affected joint<br />(c) Attacks frequently occur in the middle of the night<br />(d) An untreated attack may last up to 2 weeks<br />(e) The first attack usually involves only one joint, most frequently the big toe (first metatarsophalangeal joint)<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />49. TNF­ais an example of eicosanoids<br /><br />(a) Interleukins<br />(b) Cytotoxic factors<br />(c) Interferons<br />(d) Colony stimulating factors<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />50. Potential adverse effects associated with aspirin include all of the following except<br />(a) Gastrointestinal ulceration<br />(b) Renal dysfunction<br />(c) Enhanced methotrexate toxicity<br />(d) Cardiac arrhythmias<br />(e) Hypersensitivity asthma<br /><input color="black" onclick="value=("Answer : E ")" type="button" value="Show Answer" /><br /><br />51. All of the following facts are true about non­steroidal anti­inflammatory drugs (NSAIDs) except<br />(a) They are antipyretic<br />(b) There is a celling effect to their analgesia<br />(c) They can cause tolerance<br />(d) They do not cause dependence<br />(e) They are anti­inflammatory<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />52. Which of the following narcotics has the longest duration of effect?<br />(a) Methadone<br />(b) Controlled­release morphine<br />(c) Levorphanol<br />(d) Transdermal fentanyl<br />(e) Dihydromorphone<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />53. Cylcoocygenase­II specific inhibitors block the following<br />(a) Production of cytoprotective prostaglandins<br />(b) Tumor necrosis factor ­ a<br />(c) Production of prostaglandins responsible for pain and inflammation<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />54. The emetic action of morphine is due to<br />(a) Irritation of gastrointestinal tract<br />(b) Stimulation of cerebral cortex<br />(c) Stimulation of medullary vomiting center<br />(d) Stimulation of emetic chemoreceptor trigger zone<br />(e) None of the above<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />55. Colchicine is used mainly to treat<br />(a) Gout<br />(b) Arthiritis<br />(c) Diabetes<br />(d) Carcinomas<br />(e) High blood pressure<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />56. Which type of patient is most likely to hypersensitive to aspirin?<br />(a) Intrinsic asthamatic<br />(b) Extrinsic asthamatic<br />(c) Chronic bronchitic<br />(d) Patient with viral injection<br />(e) Both (c) and (d)<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />57. Codeine acts as a cough sedative by<br />(a) Producing mild nausea<br />(b) Depressing bronchiolar secretions<br />(c) Depressing pulmonary action<br />(d) Depressing cough center<br />(e) Paralyzing sensory nerves of bronchi<br /><br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />58. The greatest threat from morphine poisoning is<br />(a) Renal shutdown<br />(b) Paralysis of spinal cord<br />(c) Respiratory depression<br />(d) Cardiovascular collapse<br />(e) None of the above<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />59. A very common side effect of morphine is<br />(a) Allergic response<br />(b) Blood dyscrasias<br />(c) Constipation<br />(d) Liver damage<br />(e) Visceral pain<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />60. Eicosanoids are a group of _____ carbon unsaturated fatty acids<br />(a) 20<br />(b) 10<br />(c) 25<br />(d) 35<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br /><br /></div><div class="content_4" style="display: none;">61. Which of the following durgs is a monamine oxidase inhibitor, but is used to treat hypertension?<br />(a) Tranylcypromine (Parnate)<br />(b) Reserpine<br />(c) Propranolol (Inderal)<br />(d) Pargyline (Eutonyl)<br />(e) Imipramine (Tofranil)<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />62. Autacoids differ from hormones in that<br />(a) Autacoids are involved only in the causation of pathological states<br />(b) Autacoids do not have a specific cell/ tissue of origin<br />(c) Autacoids generally act locally at the site of generation and release<br />(d) Both (b) and (c)<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />63. Which of the following eicosanoids is generated through the lipozygenase pathway ?<br />(a) Prostaglandin E2<br />(b) Thromboxane A2<br />(c) Prostacyclin<br />(d) Leukotriene C4<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />64. The cyclooxygenase isoenzymes COX­1 and COX­2 differ from each other in that<br />(a) They catalyse different pathways in prostanoid biosynthesis<br />(b) COX–1 is inhibited by aspirin but not COX–2<br />(c) COX–2 is inhibited by ibuprofen but not COX–1<br />(d) COX–1 is constitutive while COX–2 is inducible<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />65. Which of the following is an irreversible inhibitor of cyclooxygenase ?<br />(a) Aspirin<br />(b) Phenylbutazone<br />(c) Indomethacin<br />(d) Piroxicam<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />66. The prostanoid that consistently constricts blood vessels is<br />(a) Prostaglandin E2<br />(b) Prostaglandin F2a<br />(c) Thromboxane A2<br />(d) Prostacyclin<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />67. The following prostanoid is a potent inducer of platelet aggregation<br />(a) Prostacyclin<br />(b) Prostaglandin E2<br />(c) Prostaglandin D2<br />(d) Thromboxane A2<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />68. Aspirin in low doses produces longlasting inhibition<br />(a) Platelets contain low quantity of COX<br />(b) Platelets cannot synthesize fresh COX molecules<br /><br />(c) Platelets bind aspirin with high affinity<br />(d) Platelet COX is inducible<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />69. The early pregnancy uterus is sensitive to the following oxytocic<br />(a) Oxytocin<br />(b) Methylergometrine<br />(c) Prostaglandin F2a<br />(d) Both (a) and (b)<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />70. Cervical priming with prostaglandin results in<br />(a) Facilitation of sperm movement through cervical canal<br />(b) Increased cervical tone<br />(c) Softening of cervix<br />(d) Increased cervical secretions<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />71. Corticosteroids exert anti­inflammatory action by inhibiting the following enzyme<br />(a) Cycloxygenase<br />(b) Lipozygenase<br />(c) Phospholipase ­ A<br />(d) Phosphodiesterase<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />72. Main effect of sulphinpyrazone in hyperuricaemia is<br />(a) Suppress the symptoms<br />(b) Promote the elimination of urate<br />(c) prevent urate synthesis<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />73. Which of the following glucocorticoids has significant mineralocorticoid activity also ?<br />(a) Hydrocortisone<br />(b) Triamcinolone<br />(c) Dexamethasone<br />(d) Betamethasone<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />74. Corticosteroid therapy is practically mandatory in the following condition.<br />(a) Septic shock<br />(b) Renal transplant<br />(c) Rheumatoid arthritis<br />(d) Ulcerative colitis<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />75. For limiting cerebral edema due to brain tumour, the preferred corticosteroids are<br />betamenthasone/dexamethasone because<br />(a) They do not cause Na+ and water retention<br />(b) They are more potent<br />(c) They can be administered intravenously<br />(d) They inhibit brain tumours<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />76. Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of<br />(a) Exfoliative dermatitis<br />(b) Posterior uveitis<br />(c) Acute rheumatic fever<br />(d) Hodgkin’s disease<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />77. The following adverse effect of corticosteroids is due to their mineralocorticoid action<br />(a) Osteoporosis<br />(b) Rise in blood pressure<br />(c) Moon face<br />(d) Increased susceptibility to infection<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />78. Which of the following bones is affected more by glucocorticoid induced osteoporosis?<br />(a) Femur<br />(b) Humerus<br />(c) Radius<br />(d) Lumber vertebra<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />79. Morphine produces analgesia by acting at<br />(a) Peripheral pain receptors<br />(b) A spinal site<br />(c) Suspraspinal sites<br />(d) Both (b) and (c)<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />80. In man sedation caused by morphine is characterized by<br />(a) Initial excitement<br />(b) Little or no motor incoordination<br />(c) Rise in seizure threshold<br />(d) All of the above<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br /><br /></div><div class="content_5" style="display: none;">81. Instead of depressing, morphine stimulates<br />(a) Vasomotor centre<br />(b) Edinger westphal nucleus<br />(c) Temperature regulating centre<br />(d) Cough centre<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />82. In a comatose patient suspected of poisoning, which of the following findings would be against the drug<br />being morphine<br />(a) Selegiline<br />(b) Chlorgiline<br />(c) Moclobemide<br />(d) Tranylcypromine<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />83. Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout<br />(a) Indomethacin<br />(b) Diclofenac<br />(c) Piroxicam<br />(d) Aspirin<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />84. Morphine dependence is characterized by<br />(a) Marked drug seeking behavior<br />(b) Physical dependence without psychic dependence<br />(c) Physical as well as psychic dependence<br />(d) Both (a) and (c)<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />85. Morphine is contraindicated in head injury because<br />(a) It does not relieve the pain of head injury<br />(b) It can raise intracranial tension<br />(c) It can cause constipation<br />(d) It is liable to cause addiction<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />86. Which of the following opioids is more potent than morphine ?<br />(a) Pethidine<br />(b) Fentanyl<br />(c) Dextropropoxyphene<br />(d) Tramadol<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />87. Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ?<br />(a) Methadone<br />(b) Buprenorphine<br />(c) Butorphanol<br />(d) Dextropropoxyphene<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />88. Select the analgesic which acts through opioids as well as additional spinal monoaminergic mechanisms.<br />(a) Tramadol<br />(b) Ethoheptazine<br />(c) Dextropropoxyphene<br />(d) Alfentanil<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br />89. An opioid analgesic is preferred over aspirin like analgesic in the following condition.<br />(a) Acute gout<br />(b) Burn<br />(c) Toothache<br />(d) Neuralgia<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />90. Morphine has high affinity for the following opioid receptor(s).<br />(a) µ (Mu)<br />(b) k (Kappa)<br />(c) d (Delta)<br />(d) All of these<br /><input color="black" onclick="value=("Answer : A. ")" type="button" value="Show Answer" /><br /><br /><br />91. Which of the following is an agonistantagonist type of opioid analgesic<br />(a) Pethidine<br />(b) Pentazocine<br />(c) Fentanyl<br />(d) Buprenorphine<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />92. Pentazocine differs from morphine in that<br />(a) It is inactive by the oral route<br />(b) It does not produce physical dependence<br />(c) It has a lower ceiling of analgesic effect<br />(d) Its action is not blocked by naloxone<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />93. Which action of morphine is incompletely reversed by naloxone ?<br />(a) Analgesia<br />(b) Respiratory depression<br />(c) Sedation<br />(d) Miosis<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />94. Lower dose of naloxone is required to<br />(a) Antagonise the actions of nalorphine<br />(b) Antagonise the actions of pentazocine<br />(c) Precipitate withdrawal in mildly morphine dependent subjects<br />(d) Precipitate withdrawal in highly morphine dependent subjects<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />95. Following mediators are involved in acute inflammation except<br />(a) Histamine<br />(b) Leukotrienes<br />(c) Interferons<br />(d) Bradykinin<br /><input color="black" onclick="value=("Answer : C. ")" type="button" value="Show Answer" /><br /><br />96. The distinctive feature of the isoenzyme cyclooxygenase­2 is<br />(a) It is not inhibited by indomethacin<br />(b) It is inducible<br />(c) It generates cytoprotective prostagladins in gastric mucosa<br />(d) It is found only in foetal tissues<br /><input color="black" onclick="value=("Answer : B. ")" type="button" value="Show Answer" /><br /><br />97. Aspirin produces analgesia by<br />(a) Preventing sensitization of peripheral pain receptors<br />(b) Affecting gating of pain impulses at spinal level<br />(c) Raising pain threshold at subcortical level<br />(d) Both (a) and (b)<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br />98. Aspirin reduces fever by<br />(a) Decreasing heat production in the body<br />(b) Enhancing cutaneous blood flow<br />(c) Inducing sweating<br />(d) Both (b) and (c)<br /><input color="black" onclick="value=("Answer : D ")" type="button" value="Show Answer" /><br /><br /><br /></div><div><script language="JavaScript1.2" type="text/javascript"> //The functions disableselect() and reEnable() are used to return the status of events. function disableselect(e) { return false } function reEnable() { return true } //if IE4 // disable text selection document.onselectstart=new Function ("return false") //if NS6 if (window.sidebar) { //document.onmousedown=disableselect // the above line creates issues in mozilla so keep it commented. document.onclick=reEnable } function clickIE() { if (document.all) { (message); return false; } } </script></div><div class="post-pagination"><a class="button_1" href="#1">PART 1</a><a class="button_2" href="#2">PART 2</a><a class="button_3" href="#3">PART 3</a><a class="button_4" href="#4">PART 4</a><a class="button_5" href="#5">PART 5</a></div></div></div>

analgesics antipyretics mcq staff nurse staffnursemcq Most Asked 100 MCQ from Analgesics and Antipyretics for Staff Nurse

1. â­-Aminoethylimidazole is? (a) 2­methyl histamine (b) Histamine (c) 2­pyridyl ethylamine (d) 4­methyl histamine 2. Agents that often caus...

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